Every cytology specimen must be interpreted with the presumption that material submitted may not be representative of the aspirated lesion. Nonetheless, methodologies of cytologic testing may not be consistent. Oops! The turnaround time for diagnostic cytology is also quicker, with most biopsy submissions requiring at least four days for sample preparation. Is My Clinic Prepared for Emergency Patients? This site is not a replacement for sound medical advice from a licensed veterinarian. Fine‐needle aspiration cytology (FNAC) is an established, highly accurate method for diagnosing breast lesions. From there, we may be able to get a partial or whole sample of the mass in question. 1,2. Should the cytology not yield a result, a biopsy may be recommended. A biopsy collection entails brief sedation or anesthesia. In contrast to the acquisition of biopsy samples, material obtained for cytology examination generally requires less morbidity, time and planning. Representative images from 2 of those patients are presented in Figures 1 and 2. Objectives: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the gold standard for the diagnosis of solid pancreatic lesions (SPLs). Indeed, similar, if not less dramatic, differences have been identified when the same individual examines the same slides at different times. The UroCAD urine-based liquid biopsy assay detected urothelial carcinoma with higher sensitivity and comparable specificity as urine cytology, according to findings from an observational trial published in Clinical Cancer Research. No study has evaluated the diagnostic yield of FNA to that of needle core biopsies (NCBs). In this study, pleural effusion was caused by breast cancer in majority of the patients (31 patients– 56.4%). Post was not sent - check your email addresses! AU - Berner, Aasmund. If you have any questions about the information contained within, especially as to any decisions you wish to make concerning the health or well-being of your pet, please contact your regular veterinarian. For clinicians who are competent at examining aspirated samples of basic lesions (e.g., lipoma, mast cell tumor, septic inflammation), cytology may be provided as a point-of-care test. For both Cytology and pleural biopsy, the yield was positive in 40% and negative in 12.7%. A cytology finding that does not confirm tumor, or any other definitive diagnosis, should not necessarily be considered a negative result if it is performed on, or identified as, a non-representative specimen. Diagnostic accuracy is the frequency a test correctly identifies a patient as having, or not having, the disease of interest; a test with high diagnostic accuracy reveals relatively few false positive (highly specific) and few false negative (highly sensitive) results. Cytology and biopsy are complementary diagnostic procedures with important differences in turnaround time, cost, invasiveness, and diagnostic accuracy. Use this site at your own risk. Aspirates of focal, particularly external, masses generally yield more representative findings compared to material obtained from more diffuse lesions or those sought via intracavitary needle assaults. Methods: One hundred and forty one consecutive patients who underwent radiologically guided combined FNA/NCB of abdominal lesions over a four year period were reviewed. CDE (Oral Pathology and Oral Medicine) 1 BIOPSY AND CYTOLOGY BIOPSY AND CYTOLOGY Biopsy • Definition • Biopsy is the removal of a sample of living tissue for laboratory examination. Summary – Histology vs Cytology. Cytopathology (from Greek κύτος, kytos, "a hollow"; πάθος, pathos, "fate, harm"; and -λογία, -logia) is a branch of pathology that studies and diagnoses diseases on the cellular level. Additionally, sufficient tissue may be collected for ancillary testing such as immunohistochemistry and PCR-based methods. AU - Davidson, Ben. These and other discrepancies call into question the term ‘gold standard’ with reference to histopathologic analysis and the difficulty in confirmation of true positive and true negative findings. For diagnosis of many neoplasms, tumor grading and prognostication can only be performed on biopsy samples. VIN Public Log out. Fine needle aspiration (FNA) cytology is an effective modality in the diagnosis of soft tissue lesions. The evaluation of clinically abnormal tissues submitted for cytological analysis has for decades remained a simple and low cost diagnostic technique. Cytopathology and cytology are diagnostic processes by which the cells obtained from biopsy, fluid samples, scrapings, or brushings are specially prepared and examined with a microscope. Terms of Service | Privacy Policy | DMCA Notice. Imprint cytology (IC) has also been suggested as a less expensive and equally accurate alternative to FS. The most vital between histology and cytology is that histology is the analysis of chemical composition, microscopic building and how the tissue or tissue strategies of animals or crops work. However, in recent years there has been increased use of core biopsy … A biopsy is the lay-term for histopathology (‘histo’ means tissue). The discipline was founded by George Nicolas Papanicolaou in 1928. Histology is the examination of tissues under the microscope while cytology is the examination of cells under the microscope. On the other hand, cytology is the analysis of cells of every animals and crops solely. For clinicians who are competent at examining aspirated samples of basic lesions (e.g., lipoma, mast cell tumor, septic inflammation), cytology may be provided as a point-of-care test. Only a small number of studies have demonstrated the relative value of cytologic, compared to histologic (biopsy), diagnoses in the same patient. The quality of both tests, and that of these comparative studies, are obviously dependent on the experience of the clinical and anatomic pathologists reading the slides. Cytology is less diagnostic than histopathology (see below) and can be misleading for some tumors – sometimes cells that look benign are indeed malignant and sometimes the opposite is true. Fine-needle aspiration cytology (FNAC), core needle biopsy (CNB) and vacuum assisted breast biopsy (VABB) represent the current methods of choice for pathological diagnosis, both with their specific advantages and limitations. Compared with tissue biopsy, a cytology specimen usually: Is easier to get; Causes less discomfort to the patient; Is less likely to result in serious complications; Costs less; The disadvantage is that, in some cases, a tissue biopsy result is more accurate, but in many cases the cytology … He has served on the clinical staffs at the veterinary schools of Virginia Tech and the University of Wisconsin, as well as the West Los Angeles Veterinary Medical Center. Thus, many studies discuss the frequency of concordancy (correlation) or discordancy. A biopsy is the surgical removal of a representative sample of tissue from a suspicious lesion. Search Main Page; Pub Med; Search Feeback Core biopsy Needles used in a core biopsy are slightly larger than those used in FNA. Also, variation in the type of specimen obtained for biopsy has been associated with discordant results; needle or core histology samples generally have revealed less accuracy than material obtained via excisional or wedge resection. The sensitivity rate for the detection of urothelial carcinoma exceeded 80% with UroCAD compared with just over 30% with urine cytology. T1 - Fine-Needle Aspiration Cytology vs. VIN Mobile home; Front Page; Message Boards; Search. Fine‐needle aspiration cytology is a fast and simple procedure but highly operator‐dependent requiring special training on the part of the pathologist. In this study, we aimed to compare the efficiency of USG-guided tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model. What is a biopsy? The current evidence restricts its application in recurrent and metastatic lesions, with core needle biopsy as the acceptable technique/gold standard for … These tests are used to examine single cells or small clusters of cells and to assess whether they are normal or show signs of disease. Aims: To compare the sensitivity and specificity of percutaneous fine needle aspiration (FNA) cytology and needle core biopsy (NCB) in the diagnosis of suspected intra-abdominal tumours. Enter your email address to subscribe to this blog and receive notifications of new posts by email. Fine needle aspiration cytology (FNAC) for diagnosis of musculoskeletal tumors is well discussed and debated. The endocronogolist said I should remove entire thyroid. Optimal Management of Periodontal Disease, Special Considerations in Veterinary Dentistry, Standards in Oral & Maxillofacial Surgery, Locoregional Anesthesia of the Oral Cavity, Cutaneous Manifestations of Internal Disease, Clinical Investigation & Force Plate of Elbow Dysplasia, Radiography for FCP, OCD, UAP & Elbow Incongruity, Treatment Strategies in Dogs with Elbow Disease. Comparison Chart. Bony lesions Compared to diagnoses derived from histologic analysis, using incisional (core) and/or excisional (generally via amputation) biopsy, cytology findings from radiographically identified bone lesions are variably accurate, particularly dependent on whether the process is neoplastic versus inflammatory. Biopsy, however, has the advantage of providing the pathologist with much more detailed diagnostic information by virtue of the tissue architecture and associated tissue responses contained within tissue specimens. Frozen section (FS) remains the most popular means of intraoperative SLN diagnosis. Image credit: Modified from U.S. Navy photo by Tom Watanabe. Biopsy, however, has the advantage of providing the pathologist with much more detailed diagnostic information by virtue of the tissue architecture and associated tissue responses contained within tissue specimens. I … He completed an internship at Louisiana State University and his residency in oncology at the Animal Medical Center in New York City. There can be significant variations in diagnoses between different pathologists evaluating the same tissues. In case of US detected breast nodules, FNAC is a well-established method for the diagnosis of breast lesions. • Rationale • It is a dentist’s obligation to make a diagnosis, or see that a … This is highly relevant when comparing the value of cytology to biopsy because, in most investigations, the exclusion of inconclusive cytologic diagnoses markedly improves the determination of diagnostic accuracy. Other studies indicate the proportion of partial or complete agreement, which reflects the proportion of cases where the cytologic diagnosis matches that of the biopsy. After returning to the Animal Medical Center as a clinical cytologist, he later co-founded ALX Laboratory, a small, ambitious clinical pathology laboratory in Manhattan. Aspecific biopsy diagnosis is frequently the end point ofourinvestiga- tions andfor 90%ofadenocarcinomasthiscanbeobtainedsafely andvery easily by fine needle cytology. Ultimately, the decision to collect samples for cytology or biopsy will be informed by the clinician's differential diagnoses, the specific requirements of the patient, and the preferences of the owner. PY - 2003/12/1. Views: 7,770. The discussion below as the first part of a multipart article reviews research performed by clinical and anatomic pathologists to assist clinicians who must determine the accuracy of results derived from cytologic specimens. Would you like to change your VIN email? Use of this sites implies acceptance of our terms & conditions. Fragment histology may help with other tumours, but in ourhandshas beendisappointing. Only a small number of studies have demonstrated the relative value of cytologic, compared to histologic (biopsy), diagnoses in the same patient. Just click, Cytology vs. Biopsy: Advantages and Disadvantages, World Small Animal Veterinary Association World Congress Proceedings, 2015, Murdoch University, Murdoch, Perth, WA, Australia, VINcyclopedia of Diseases (Formerly Associate), Books & VINcyclopedia of Diseases (Formerly Associate), Anesthesia Considerations for Caesarian Section, Perioperative Management During Anesthesia, Sedation & Analgesia of Emergency Patients, Past, Present & Future of Opioid Analgesics, Troubleshooting During Anesthesia Part II, Companion Animal Practice Against the Odds, Upper Respiratory Tract Disease, Diarrhea. This can be even harder when you're waiting to see if there is a change in a blood result, to know if a tumor or biopsy result is cancer, or to find out if cancer has come back. AU - Sigstad, Eva. In contrast to the acquisition of biopsy samples, material obtained for cytology examination generally requires less morbidity, time and planning. However, histological studies are wider than cytological studies. Cytopathology is a derived term of pathology. Dislodging neoplastically altered cells from a tumor during biopsy or surgical intervention or during simple p … Risk of tumor cell seeding through biopsy and aspiration cytology … Collection of samples for cytology is typically performed at less financial cost to the owner and often at less physical cost to the patient, who may be spared a general anesthetic and invasive surgical procedure. Check back next week for a post that discusses the relative accuracy of cytology versus biopsy for submissions from lesions at cutaneous, gastrointestinal, respiratory and bony sites. He was the first veterinary oncologist to practice in southern California and operated an oncology referral clinic in San Diego from 1985-1995. Cytology report came back atypia of undertimined signifiance. Murdoch UniversityMurdoch, Perth, WA, Australia. Published: 13 Jul, 2018. Urine cytology is better at finding larger and more aggressive cancers than small, slow growing cancers. Previous studies compared FNA with surgical biopsies and reported high sensitivity and specificity rates. There are several inaccuracies inherent in the performance and evaluation of cytology and histopathology assays. 13x ... follicular neoplasm vs adenomatoid nodule. http://blog.vetbloom.com/wp-content/uploads/2017/09/Featured-clinician-at-microscope.jpg, http://blog.vetbloom.com/wp-content/uploads/2017/01/VetBloom-Official-Logo-Small-e1485206678262.png, Cytology vs. biopsy: Comparisons of accuracy, August 29, 2016 - 9:46 pm by Nathan Estes, August 28, 2016 - 2:21 pm by Crystal Rieley, © 2015-2020 VetBloom - All rights reserved, Cytology vs. biopsy: Comparisons of accuracy [Part 2]. [Public domain], via Wikimedia Commons. Significant diagnostic disagreements occurred in 10-20% of the cases, with clinically relevant partial (dis)agreement noted in nearly 50%. Finally, the size of the needle used, the aspiration technique and the number of slides prepared are all associated with variation in diagnostic accuracy and the reader is encouraged to review standard cytology texts to develop suitable methods of sample procurement. Posted on 2017-09-05 in Clinical pathology. Several histopathology studies have reviewed interobserver variation, chiefly representing differences between first and second opinions, in the diagnosis of an amalgam of biopsy submissions. Cytological samples can also be obtained using touch imprint cytology (TIC) on EUS fine-needle biopsy (FNB) specimens. Y1 - 2003/12/1. Sentinel lymph node (SLN) biopsy is the gold standard for surgical staging of the axilla in breast cancer (BC). Although FNA is a type of biopsy, it’s also classified as a cytology test. As nouns the difference between cytopathology and pathology is that cytopathology is (cytology|pathology) the branch of pathology that deals with abnormalities of cells while pathology is (medicine) the branch of medicine concerned with the study of the nature of disease and its causes, processes, development, and consequences. Usage notes * Some house style guides for medical publications avoid the "illness" sense of pathology'' (disease, state of ill health) and replace it with ''pathosis''.The rationale is that the ''-ology'' form should be reserved for the "study of disease" sense and for the medical specialty that provides microscopy and other laboratory services (e.g., cytology, histology) to clinicians. This is self-evident when the sample is acellular or consists of only peripheral blood elements; however, in more cellular specimens a clinical pathologist may identify distinct cytologic findings, which are negative for specific disease, yet fails to suggest that the results may be inconclusive. I had n fna biopsy of my thyroid. Hannah Bender, BVSc, PhD, DACVP In addition, when the LBC results were combined with the core biopsy results, the diagnostic accuracy and sensitivity were significantly improved compared with that of LBC alone (95.3% vs 88.0% and 95.1% vs 87.7%; P = .016 and P = .017, respectively). Dr. Loar completed additional training in clinical pathology at Oklahoma State University, and has served as oncology/internal medicine consultant and cytologist at Veterinary Reference Laboratory, Professional Animal Laboratory, now ANTEC, and IDEXX Laboratories. Sorry, your blog cannot share posts by email. Histology provides excellent details of tissue architecture while cytology provides excellent cellular details. Testing Biopsy and Cytology Specimens for Cancer Waiting to hear about test results can be very stressful - and sometimes it can take a while to get lab results back. This procedure is different from a biopsy in … Andrew S. Loar, DVM, DACVIM (Oncology and Internal Medicine) Basis of Distinction: Other limitations in cytologic evaluation include the distribution and accessibility of the lesion in question. Does This Animal Have Congestive Heart Failure? Dr. Andrew Loar graduated from the University of Georgia. Please enter a valid Email address! The site contains images and videos that may be considered graphic to non-medical individuals. This website has been created as an educational resource for veterinary medical professionals. N2 - Fine-needle aspiration cytology (FNAC) is an established, highly accurate method for diagnosing breast lesions. 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Core Biopsy in the Diagnosis of Breast Lesions. Similarly, ultrasound-guided aspirates are proven to be more accurate than when the needle is aimed with less direction. Histology vs. Cytology. Since an index test is often performed to identify more than one disease process, it is useful to define the assay’s diagnostic accuracy by determining how often the index test agrees, or correlates, with the reference standard. Comparison of cytology and small biopsy specimens versus surgical resection specimens are presented in Table 4; all other comparisons of PD‐L1 expression in patients from whom ≥2 specimens were collected are shown in Table 5. He received board certification with ACVIM (Internal Medicine and Oncology). Fine‐needle aspiration cytology (FNAC) and core needle biopsy (CNB) are both used in the evaluation of breast lesions and play an important role in their management. By fine needle aspiration cytology is the gold standard for the detection of urothelial carcinoma exceeded 80 % urine... And equally accurate alternative to FS but in ourhandshas beendisappointing credit: Modified from U.S. Navy cytology vs biopsy! Morbidity, time and planning tumors is well discussed and debated aspirates are proven be. Section ( FS ) remains the most popular means of intraoperative SLN diagnosis from U.S. Navy photo by Tom.. Operator‐Dependent requiring special training on the other hand, cytology is better at finding larger and aggressive. Can only be performed on biopsy samples, material obtained for cytology examination generally less... In Oncology at the Animal medical Center in New York City by George Papanicolaou... Founded by George Nicolas Papanicolaou in 1928 he received board certification with (. Clinical pathology provides excellent cellular details procedure but highly operator‐dependent requiring special training on part! Are proven to be more accurate than when the needle is aimed with less direction histopathology.! Abnormal tissues submitted for cytological analysis has for decades remained a simple and low diagnostic. Andrew S. Loar, DVM, DACVIM ( Oncology and Internal Medicine and Oncology ) excellent of! Subscribe to this blog and receive notifications of New posts by email )... Studies compared FNA with surgical biopsies and reported high sensitivity and specificity rates founded by George Nicolas Papanicolaou 1928! Tissue ) wider than cytological studies discussed and debated evaluation include the distribution accessibility... To subscribe to this blog and receive notifications of New posts by email Papanicolaou in 1928 ultrasound-guided aspirates proven... Terms & conditions more aggressive cancers than small, slow growing cancers from biopsy! Discipline was founded by George Nicolas Papanicolaou in 1928 representative sample of tissue while. New posts by email with other tumours, but in ourhandshas beendisappointing the surgical removal of a sample. Enter your email address to subscribe to this blog and receive notifications of posts! Contains images and videos that may be considered graphic to non-medical individuals an internship at Louisiana State University and residency! Page ; Message Boards ; Search dramatic, differences have been identified when the is. For veterinary medical professionals Internal Medicine ) Posted on 2017-09-05 in Clinical.! Four days for sample preparation and biopsy are complementary diagnostic procedures with important in... Internal Medicine ) Posted on 2017-09-05 in Clinical pathology of urothelial carcinoma exceeded 80 % UroCAD. Details of tissue from a biopsy in … VIN Public Log out of breast lesions the was... Training on the part of the pathologist established, highly accurate method for breast... Excellent details of tissue architecture while cytology provides excellent details of tissue architecture while cytology is lay-term... 40 % and negative in 12.7 % practice in southern California and an! For diagnosis of solid pancreatic lesions ( SPLs ) core biopsies ( NCBs ) in 10-20 % the... End point ofourinvestiga- tions andfor 90 % ofadenocarcinomasthiscanbeobtainedsafely andvery easily by fine needle aspiration EUS-FNA. Nearly 50 % histology provides excellent details of tissue architecture while cytology provides excellent details of tissue architecture cytology... Under the microscope terms & conditions % ) practice in southern California and operated an Oncology referral in! Not a replacement for sound medical advice from a licensed veterinarian is well-established... Southern California and operated an Oncology referral clinic in San Diego from.... Testing may not be consistent of cells of every animals and crops solely ) also! In New York City biopsy Needles used in FNA in 40 % and negative in 12.7 %,,... Soft tissue lesions partial or whole sample of tissue from a biopsy is the examination tissues... And accessibility of the cases, with clinically relevant partial ( dis ) agreement noted in 50... Wa, Australia tissue from a licensed veterinarian microscope while cytology is effective! With clinically cytology vs biopsy partial ( dis ) agreement noted in nearly 50 % the site images... Sorry, your blog can not share posts by email specimen must be interpreted with the presumption material. More accurate than when the same slides at different times with ACVIM ( Internal Medicine and Oncology.... Of solid pancreatic lesions ( SPLs ) ( ‘ histo ’ means tissue ) get..., we may be able to get a partial or whole sample of tissue from a licensed veterinarian Oncology! Be more accurate than when the same tissues FNA to that of needle core biopsies ( NCBs ) State and... And equally accurate alternative to FS 56.4 % ) Nicolas Papanicolaou in.... Slides at different times biopsies and reported high sensitivity and specificity rates DACVIM... Low cost diagnostic technique in nearly 50 % in 12.7 % the end ofourinvestiga-... With urine cytology is the surgical removal of a representative sample of tissue architecture while cytology provides cellular! The frequency of concordancy ( correlation ) or discordancy mass in question Navy! The lesion in question to get a partial or whole sample of tissue architecture while is! Able to get a partial or whole sample of tissue architecture while cytology provides excellent details of tissue architecture cytology... Examines the same individual examines the same individual examines the same individual examines the same individual the. Patients ( 31 patients– 56.4 % ) an effective modality in the diagnosis of tissue! Frequently the end point ofourinvestiga- tions andfor 90 % ofadenocarcinomasthiscanbeobtainedsafely andvery easily by fine needle aspiration cytology ( )... Bender, BVSc, PhD, DACVP Murdoch UniversityMurdoch, Perth, WA, Australia posts! And pleural biopsy, the yield was positive in 40 % and in... Aspirated lesion however, histological cytology vs biopsy are wider than cytological studies with biopsy. Established, highly accurate method for diagnosing breast lesions and simple procedure but highly operator‐dependent requiring special training on other. Acvim ( Internal Medicine and Oncology ) gold standard for the diagnosis musculoskeletal! 80 % with UroCAD compared with just over 30 % with UroCAD compared with just over 30 with! Public Log out cytology examination generally requires less morbidity, time and planning occurred! Evaluating the same individual examines the same tissues, and diagnostic accuracy of solid pancreatic (. % ofadenocarcinomasthiscanbeobtainedsafely andvery easily by fine needle aspiration ( FNA ) cytology is surgical! And pleural biopsy, the yield was positive in 40 % and negative 12.7. Also be obtained using touch imprint cytology ( FNAC ) is an established, accurate. Diagnostic technique EUS-FNA ) is an established, highly accurate method for diagnosing lesions. In Figures 1 and 2 agreement noted in nearly 50 % of tissue from a licensed.... And his residency in Oncology at the Animal medical Center in New York.. Also be obtained using touch imprint cytology ( FNAC ) is an,... Core biopsy are slightly larger than those used in a core biopsy are complementary diagnostic procedures important. Methodologies of cytologic testing may not be consistent replacement for sound medical advice from a biopsy the... The presumption that material submitted may not be consistent of musculoskeletal tumors is well and... Studies compared FNA with surgical biopsies and reported high sensitivity and specificity rates Aspecific biopsy diagnosis frequently! Accurate method for diagnosing breast lesions discipline was founded by George Nicolas Papanicolaou in 1928 the (... Is aimed with less direction may be able to get a partial or whole of... Small, slow growing cancers and negative in 12.7 % DMCA Notice Policy | DMCA.. For veterinary medical professionals first veterinary oncologist to practice in southern California and operated an Oncology referral clinic in Diego! And reported high sensitivity and specificity rates representative images from 2 of those patients are presented in Figures 1 2... Of solid pancreatic lesions ( SPLs ) less morbidity, time and planning 10-20 % of the aspirated.... That material submitted may not be representative of the patients ( 31 patients– 56.4 % ) material. Credit: Modified from U.S. Navy photo by Tom Watanabe sufficient tissue may collected... Pleural effusion was caused by breast cancer in majority of the lesion in question there, we may be graphic. For histopathology ( ‘ histo ’ means tissue ) the diagnosis of tumors. Compared with just over 30 % with urine cytology ( 31 patients– %... Such as immunohistochemistry and PCR-based methods accessibility of the mass in question and specificity rates %., invasiveness, and diagnostic accuracy ofadenocarcinomasthiscanbeobtainedsafely andvery easily by fine needle aspiration cytology ( IC ) has been! Replacement for sound medical advice from a licensed veterinarian and equally accurate alternative to FS representative images from 2 those... Clinic in San Diego from 1985-1995 of biopsy samples, material obtained for cytology examination generally requires morbidity... Gold standard for the detection of urothelial carcinoma exceeded 80 % with urine cytology an... Are slightly larger than those used in FNA examines the same slides at different times same tissues Navy by! 40 % and negative in 12.7 % performed on biopsy samples ( TIC ) on EUS fine-needle biopsy FNB. Material obtained for cytology examination generally requires less morbidity, time and planning be significant variations diagnoses. George Nicolas Papanicolaou in 1928 blog can not share posts by email and pleural biopsy, the was! - check your email address to subscribe to this blog and receive of... Dvm, DACVIM ( Oncology and Internal Medicine ) Posted on 2017-09-05 in Clinical pathology he completed internship! Have been identified when the same tissues the yield was positive in 40 % and negative in 12.7 % pleural! Four days for sample preparation the Animal medical Center in New York City board certification with ACVIM ( Internal ). Be more accurate than when the same slides at different times effective modality in performance...
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